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KMID : 0613820090190060735
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Journal of Life Science
2009 Volume.19 No. 6 p.735 ~ p.743
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Naringin Protects Ovalbumin-induced Asthma through the Down-regulation of MMP-9 Activity and GATA-3 Gene
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Lee Chang-Min
Shin Yong-Kyoo
Park Hee-Ju
Kim Jong-Suk
Chang Jeong-Hyun
Jung In-Cuk
Jeong Young-Il
Tae Noh-Kyung
Park Sung-Nam
Park Yeong-Min
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Abstract
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The common word flavonoids is often used to classify a family of natural compounds, highly abundant in all higher plants, that have received significant therapeutic interest in recent years. Naringin is associated with a reduced risk of heart disease, neurodegenerative disease, cancer and other chronic diseases; however the molecular basis of this effect remains to be elucidated. Thus we attempted to elucidate the anti-allergic effect of Naringin in ovalbumin (OVA)-induced asthma model mice. The OVA-induced mice showed allergic reactions in the airways. These included an increase in the number of eosinophils in bronchoalveolar lavage (BAL) fluid, an increase in inflammatory cell infiltration into the lung around blood vessels and airways, airway luminal narrowing, and the development of airway hyper-responsiveness (AHR). The administration of Naringin before the last airway OVA challenge resulted in a significant inhibition of all asthmatic reactions. Accordingly, this study may provide evidence that Naringin plays a critical role in the amelioration of the pathogenetic process of asthma in mice. These findings provide new insight into the immunopharmacological role of Naringin in terms of its effects on asthma in mice.
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KEYWORD
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Naringin, asthma, GATA-3, AHR, IgE
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